2,4-Difluoroaniline

CAS367-25-9

Sifofin sinadarai: abu mai launin rawaya mai haske.

Amfani: 2,4-Difluoroaniline matsakaici ne a cikin haɗakar kwayoyin halitta. A cikin magunguna, ana amfani da shi wajen haɗa difluorophenylsalicylic acid da polyfluorodiphenyl acid. Difluorophenylsalicylic acid magani ne na carboxylic acid wanda ba shi da steroidal anti-inflammatory (NSAID), tare da sunan ƙasa da ƙasa (INN) Diflunisal. Wannan sabon sinadari na salicylic acid, kodayake ba shi da rukunin acetyl na aspirin, ya ƙunshi rukunin difluorophenyl, wanda ke haifar da ƙarancin tasirin antiplatelet, ƙananan halayen gastrointestinal, da tsawon lokacin aiki na tsawon awanni 8-12. Wataƙila shine maganin salicylic acid mafi kyau. Hakanan muhimmin matsakaici ne a cikin samar da magungunan kashe kwari.

Tsarin kwayoyin halitta C6H5F2N,

nauyin kwayoyin halitta 129.11,

Lambar EINECS 206-687-5

Wurin narkewa -7.5 °C (haske)

Tafasawar zafin jiki 170 °C/753 mmHg (lit.)

Yawan 1.268 g/mL a 25 °C (lit.)

Ma'aunin haske n20/D 1.506 (lit.)

Wurin walƙiya 145°F

Hanyar Samarwa 1. Hanyar Rage Difluoronitrobenzene ta 2,4: Ana ƙara foda na ƙarfe da ruwan ammonium chloride a cikin wani reactor mai ragewa, ana dumama shi zuwa reflux, sannan a ƙara 2,4-difluoronitrobenzene a hankali. Bayan an gama ƙarawa, sai a sake yin reflux na tsawon awanni 2. Bayan an gama aikin, ana tace samfurin ta tururi, an raba shi da Chemicalbook, sannan a busar da shi da calcium chloride don samun ingantaccen samfurin da ke da yawan amfanin ƙasa na 87%. 2. An samo shi daga 1,2,4-trichlorobenzene ta hanyar nitration, fluorination, da reductive dechlorination; ko kuma an samo shi daga m-phenylenediamine ta hanyar diazotization, maye gurbinsa, nitration, da ragewa.

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